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Nomegestrol acetate
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Nomegestrol acetate : ウィキペディア英語版
Nomegestrol acetate

Nomegestrol acetate (INN; Lutenyl), or 19-normegestrol acetate, is a steroidal progestin with additional antigonadotropic effects which was introduced in 1986 and is used as a hormonal contraceptive. Unlike many other steroidal progestogens, it is selective for the progesterone receptor, lacking any significant affinity for other steroid receptors such as the androgen, estrogen, glucocorticoid, and mineralocorticoid receptors. As a result, it does not possess any androgenic, estrogenic, glucocorticoid, or mineralocorticoid effects. However, at sufficiently high doses it does have potent antiestrogenic and antiandrogenic effects due to its progesterone receptor-mediated antigonadotropic properties.
The combination with estradiol is also used as a hormonal contraceptive and approved in Europe under the name Zoely.〔European Medicines Agency: (Zoely )〕
==See also==

* Nomegestrol
* Demegestone
* Trimegestone
* Megestrol acetate
* Progestin

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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